Beta 2-agonist fenoterol has greater effects on contractile function of rat skeletal muscles than clenbuterol.
نویسندگان
چکیده
Potential treatments for skeletal muscle wasting and weakness ideally possess both anabolic and ergogenic properties. Although the beta(2)-adrenoceptor agonist clenbuterol has well-characterized effects on skeletal muscle, less is known about the therapeutic potential of the related beta(2)-adrenoceptor agonist fenoterol. We administered an equimolar dose of either clenbuterol or fenoterol to rats for 4 wk to compare their effects on skeletal muscle and tested the hypothesis that fenoterol would produce more powerful anabolic and ergogenic effects. Clenbuterol treatment increased fiber cross-sectional area (CSA) by 6% and maximal isometric force (P(o)) by 20% in extensor digitorum longus (EDL) muscles, whereas fiber CSA in soleus muscles decreased by 3% and P(o) was unchanged, compared with untreated controls. In the EDL muscles, fenoterol treatment increased fiber CSA by 20% and increased P(o) by 12% above values achieved after clenbuterol treatment. Soleus muscles of fenoterol-treated rats exhibited a 13% increase in fiber CSA and a 17% increase in P(o) above that of clenbuterol-treated rats. These data indicate that fenoterol has greater effects on the functional properties of rat skeletal muscles than clenbuterol.
منابع مشابه
2-Agonist fenoterol has greater effects on contractile function of rat skeletal muscles than clenbuterol
Ryall, James G., Paul Gregorevic, David R. Plant, Martin N. Sillence, and Gordon S. Lynch. 2-Agonist fenoterol has greater effects on contractile function of rat skeletal muscles than clenbuterol. Am J Physiol Regul Integr Comp Physiol 283: R1386–R1394, 2002. First published September 5, 2002; 10.1152/ajpregu.00324.2002.—Potential treatments for skeletal muscle wasting and weakness ideally poss...
متن کاملThe 2-agonist fenoterol has greater effects on contractile function of rat skeletal muscles than clenbuterol
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Beta2-adrenoceptor agonist fenoterol enhances functional repair of regenerating rat skeletal muscle after injury.
Beta(2)-adrenoceptor agonists such as fenoterol are anabolic in skeletal muscle, and because they promote hypertrophy and improve force-producing capacity, they have potential application for enhancing muscle repair after injury. No previous studies have measured the beta(2)-adrenoceptor population in regenerating skeletal muscle or determined whether fenoterol can improve functional recovery i...
متن کاملEffects of beta(2)-agonist clenbuterol on biochemical and contractile properties of unloaded soleus fibers of rat.
The effects of clenbuterol beta(2)-agonist administration were investigated in normal and atrophied [15-day hindlimb-unloaded (HU)] rat soleus muscles. We showed that clenbuterol had a specific effect on muscle tissue, since it reduces soleus atrophy induced by HU. The study of Ca(2+) activation properties of single skinned fibers revealed that clenbuterol partly prevented the decrease in maxim...
متن کامل2-Adrenoceptor agonist fenoterol enhances functional repair of regenerating rat skeletal muscle after injury
Beitzel, Felice, Paul Gregorevic, James G. Ryall, David R. Plant, Martin N. Sillence, and Gordon S. Lynch. 2-Adrenoceptor agonist fenoterol enhances functional repair of regenerating rat skeletal muscle after injury. J Appl Physiol 96: 1385–1392, 2004. First published November 7, 2003; 10.1152/japplphysiol.01081.2003.— 2-Adrenoceptor agonists such as fenoterol are anabolic in skeletal muscle, a...
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عنوان ژورنال:
- American journal of physiology. Regulatory, integrative and comparative physiology
دوره 283 6 شماره
صفحات -
تاریخ انتشار 2002